CoMPLEX will hold a ONE-DAY MEETING on Friday 9 November 2007 from 10a.m-6p.m. The Meeting aims to strengthen contacts between new and existing Members of CoMPLEX, and to foster new collaborations within the research community that cross the physical/ biological science divide. The Meeting will begin with a brief introduction to CoMPLEX and will include a keynote talk, together with research talks from groups at UCL.
There is no registration fee. To register and book your place,
please email: CoMPLEX@ucl.ac.uk to confirm attendance.
Coffee, lunch and tea will be provided for those who register
by 5 November 2007. (Wine Reception will follow meeting at 6pm, location TBC).
'A Kv Channel Toxin and a Lipid Bilayer - Insights from
Atomistic and Coarse-Grained Simulations'
Abstract: Gating-modifier toxins which act on voltage-gated potassium
(Kv) channels can be used to probe the structure and dynamics of the
voltage-sensors (VS). These toxins are thought to gain access to
their target channels via the lipid bilayer phase. Here, we perform
atomistic (AT) and (CG) molecular dynamics (MD) simulations to probe
the interaction of one such toxin from spider venom (VSTx1 which
binds the VS of the archaebacterial Kv channel KvAP) with lipid
bilayers. Our results provide insights into the state-dependent
conformations of the voltage-sensors of KvAP in a membrane
environment.
24th September 2007, 4pm
CoMPLEX Seminar
Sean Megason from Caltech,
(before taking up a position at Harvard Institute for Systems Biology.)